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Zyban (Bupropion)


What is Zyban?

Zyban is a nicotine-free medication to help you stop smoking. The beauty of Zyban is that it doesn’t contain nicotine unlike other drugs (anti-smoke pills, patches, and chewing gum). Zyban tablets with bupropion hydrochloride as the active ingredient is a medicine used to help people give up smoking. Although it acts in the brain, this is not the same as nicotine replacement therapy. It is not fully understood how this drug works, but it is known that bupropion affects neurotransmitters in the brain. These neurotransmitters are chemicals stored in nerve cells and are involved in transmitting messages between them. Every time a message is transmitted, Neurotransmitters are released from nerve cells. As soon as the message is passed, the nerve cells reabsorb the neurotransmitter. Zyban (Bupropion) prevents two of these neurotransmitters (noradrenaline and dopamine) from being reabsorbed back into the nerve cells. These two are responsible for moderating mood as well as other processes in the brain.

According to medical experts, bupropion helps you quit smoking by increasing the amount of noradrenaline and dopamine in the brain. Used together with motivational support techniques, Zyban is the perfect ally to quit smoking. Seeking out for help and support will increase your chance of success. As the medicine needs time to show results, it is advisable to start taking Zyban while you are still smoking and set a 'quit date' for within the first two weeks of treatment. The usual dose is one tablet one time a day for six days. On day seven you increase to one tablet two times per day. The best option is to take your first dose when you get up in the morning and the second one at least eight hours later. Important: Please avoid taking the second dose at bedtime in order to prevent insomnia (a possible side effect of this medicine).

       Treatment Dosage Quantity Per Pill Price Buy now
Zyban Zyban 150mg 60 £2.35 £141.20 Buy Now

*Prices are subject to change due to fluctuations and may differ from the price shown for the item on the product detail page. Items in your shopping cart will always reflect the recent and final price.

Buy Zyban With an Online Prescription

An online doctor consultation means filling out a medical questionnaire. A registered EU doctor assesses your medical questionnaire and analize whether Zyban is suitable and safe for you to buy. After approval, a prescription is issued and send to the registered EU pharmacy. You will receive your discretely shipped Zyban pills within 3 business days.

Before taking Ziban®, you should carefully read the instructions. Here you will find answers to the most frequently asked questions about the use of Zyban® tablets. This instruction does not contain absolutely complete information about the drug.

All drugs have a risk of their use and benefits. Your doctor must carefully weigh the risk-benefit ratio associated with using Zyban and make the right decision for you.

If you have any questions about taking the drug, you should consult with a specialist or pharmacist. Keep this liner with the drug. You may need to read it again.

Indications for use

Ziban® tablets contain bupropion hydrochloride. The exact mechanism of action of this active substance is completely unknown, but it is believed that it interacts with chemicals such as norepinephrine (norepinephrine) and dopamine (dopamine), and acts directly on the human brain.

Zyban® is a prescription drug intended for the short-term treatment of tobacco dependence with appropriate psychological counseling. In most patients, Zyban® reduces the severity of withdrawal symptoms and the desire to smoke.

Zyban® may be prescribed for another reason. Consult your healthcare provider if you have any questions about the use of Zyban® for you. Zyban® tablets are not addictive.

Before you start taking Zyban® tablets, you should be fully tuned in and show a desire to quit smoking before you start taking Zyban®.

It will be easier for you to quit smoking if you have the appropriate support from people close to you. You can tell family, friends and work colleagues that you are about to quit smoking and you need their help and support.

Contraindications

You should not take Zyban if: Have you ever had an allergic reaction to the drug Zyban ®, bupropion hydrochloride or any other component listed at the end of this manual.

An allergic reaction, both moderate and serious, is possible. Some or all of the following symptoms usually appear shortness of breath, swollen lips/mouth, difficulty breathing, hay fever (allergic rhinitis; allergic conjunctivitis), urticaria (itchy rash), or weakness and dizziness.

An allergic reaction can last a long time. You should talk to your doctor about managing allergy symptoms or stopping treatment.

  • You are currently suffering from any form of epilepsy or have ever suffered an epileptic seizure (paroxysm or convulsion).
  • You usually abuse alcohol BUT decided to quit or plan to do this because of taking Zyban®.
  • You suddenly stopped taking tranquilizers (psychotropic sedatives) or are planning to do this because of Zyban®.
  • You have a brain tumor.
  • Have you ever suffered from an eating disorder (such as bulimia or anorexia)?
  • You have been taking or have been taking medications such as monoamine oxidase inhibitors (MAOIs) for the past 14 days.
  • Are you pregnant or are planning a pregnancy; you are breast-feeding a child unless your healthcare provider recommends taking Zyban®.

In the event of pregnancy or breastfeeding, your doctor must discuss with you the possible risks and expected benefits of taking Zyban® tablets.

  • Expired on the packaging.

If you take Zyban® after the expiration date, the drug will most likely not act properly.

  • The packaging is torn or there are clear signs of tampering.

Some people tend to get depressed when they try to quit smoking; sometimes they may think of suicide, or even try to do it. These symptoms have also been observed in people taking nicotine addiction during treatment. Bupropion is an active ingredient in Zyban®, which is also used to treat depression.

People taking antidepressants sometimes think about harming themselves or committing suicide. At the beginning of antidepressant treatment, suicidal thoughts, according to the results of numerous studies, come especially often.

If you are depressed or have suicidal thoughts during treatment, seek professional help as soon as possible.

If you are not sure whether you should take Zyban®, consult your doctor about another treatment. Before you start taking Ziban®, you should inform your doctor if:

  • You are allergic to foods, dyes, preservatives, or any other medicines.
  • You are currently taking, or have been taking, a monoamine oxidase inhibitor (MAOI) for the past 14 days.
  • You are taking a natural herbal medicine based on hypericum.
  • You are taking medications to control your appetite.
  • Have you ever had a head injury?
  • You have kidney or liver disease.
  • You suffer from any kind of mental disorder, in particular, bipolar affective disorder (also known as manic-depressive psychosis).
  • You have diabetes.
  • You suffered an epileptic seizure (paroxysm) during the previous course of treatment with Zyban®.
  • You are taking medications (sedatives) to reduce anxiety.
  • You are abusing alcohol.

It is best if you do not drink alcohol at all, or in very small quantities, taking Zyban®. If you abuse alcohol, or suddenly stop drinking, while taking Zyban®, you increase the risk of seizures. In this regard, it is important to discuss alcohol consumption with your doctor before you start taking Zyban®.

Interaction with other drugs

Tell your doctor about any other medications you are currently taking (for example, medications used to treat heart disease, high blood pressure, psychological illnesses, cancer, depression, epilepsy, Parkinson's disease; muscle relaxants, drugs to prevent heart attacks), including medicines purchased in pharmacies without a doctor’s prescription, as well as funds purchased in supermarkets or dietary (healthy) food stores. This also includes nicotine chewing gums, patches, tablets and other substitutes for cigarettes.

Some drugs may affect the mechanism of action of other drugs in any way. Therefore, while taking Zyban®, it’s important not to take medicines that may increase the risk of seizures (paroxysm), for example, antimalarials, tramadol (painkiller), theophylline used in asthma, drugs to regulate appetite, sedative antihistamines, antibiotics class quinolones, steroid tablets, and injections. Make sure your doctor knows about all the medicines you are taking or plan to take.

Your doctor or pharmacist will help you determine if Zyban® will interact with other medicines. The concomitant use of Zyban® tablets and nicotine substitutes (for example, nicotine patches or chewing gums) can lead to an increase in blood pressure. Your doctor may recommend that you take regular blood pressure measurements to help determine if your blood pressure is normal.

Use in children

Zyban® is not recommended for use in children and adolescents under the age of 18 years.

How to take Zyban, treatment, and dose

Take Zyban® only if it has been prescribed to you by your healthcare provider.

The course of treatment with Zyban® includes two stages: the first stage consists of 30 tablets, the second - 90 tablets.

The first stage of 30 tablets is designed for approximately 14 days. The second stage of 90 tablets is designed for approximately 6 weeks.

In order to avoid breaks between the stages of the course, it is important to purchase 90 tablets in advance for the next stage, then you will be sure that you can continue the course immediately after the previous one. Your doctor will tell you how often and how many Zyban® tablets you should take. You will also find this information on the packaging of the drug.

If you notice a sleep disturbance during the course of treatment with the drug, try not to take Zyban® before going to bed. If you take 2 tablets per day, try to take one tablet early in the morning, the other in the afternoon. The interval between doses of tablets should be 8 hours.

The first stage of the course of treatment

For the first stage, 30 tablets of Ziban® are needed, designed for a little more than 14 days. Take as much as prescribed by your doctor. Usually, the recommended dose is 150 mg (1 tablet) once a day for the first 3 days.

On the fourth day, the dose is 150 mg (1 tablet) twice a day. The interval between doses of tablets should be at least 8 hours. Before the first stage of the treatment course ends, you should go to the doctor for a prescription for Zyban tablets for the next stage.

The second stage of the course of treatment

During the second stage of the course of treatment, 90 tablets of Ziban® are needed, designed for a little more than 6 weeks. It should be taken in accordance with the instructions of the attending physician. Usually, the recommended dose is 150 mg (1 tablet) twice daily. The interval between doses of tablets should be at least 8 hours.

In no case can you arbitrarily increase the dosage of the drug, you must adhere to the doctor’s instructions! Taking an unwritten high dose can lead to a risk of an epileptic seizure (paroxysm or convulsions). If you have liver disease, consult your healthcare provider about the possibility of treatment with Zyban®.

How long should I take Zyban®

Approximately 1 week is required for Zyban® to begin to act in the human body. Thus, quit smoking as much as possible after a week of treatment. This means that in the first week of taking the drug you continue to smoke (smoking and taking Zyban® at the same time is not dangerous). During the second week of treatment, you set the date when you stop smoking (for example, on day 10-11 of the course).

Most people need at least a 7-week treatment with Zyban®. Follow your doctor's instructions carefully. Information on how to take Zyban® tablets is also available on the package of the drug. If you have any questions about how to take Zyban®, contact your doctor or pharmacist for help.

Treatment with Ziban® and the simultaneous use of cigarette substitutes (for example, nicotine patches, chewing gums, sprays, inhalers, etc.) should be carried out only under the supervision of the attending physician.

Mode of application

Swallow the tablet whole with a little water. In no case do not crush, chew or dissolve the tablets - otherwise, the medicine will enter the body too quickly. In this case, you increase the likelihood of side effects, including an epileptic seizure (paroxysm or convulsion).

Dose skip

If you forget to take the pill on time, skip the dose and continue taking the drug as usual. Do not take a double dose to make up for a missed drug!

Overdose

In case of an overdose of Zyban® tablets, you must IMMEDIATELY seek emergency medical help and call the local poisoning center, even if there are no obvious signs of discomfort or poisoning. You may need emergency medical attention. Always have the poison center phone number on hand. If you do not know what to do, contact your doctor or pharmacist for help.

Recommendations while taking Zyban

What you must do:

  • Tell your doctor or pharmacist about all new medicines that you plan to take while taking Zyban®.
  • Tell your doctor if you are pregnant or plan to become pregnant while taking Zyban®.
  • Tell your doctor if for any reason you are not taking or have not taken Zyban® as you have been prescribed.

Otherwise, the doctor may suggest that the treatment was ineffective and without the need to change it.

  • Minimize or avoid alcohol during treatment with Zyban®.

What should not be done:

  • In no case do not stop taking the drug Ziban® and do not change its dosage without consulting your doctor.
  • Do not pass this medicine to anyone else, even if the person has the same problem of quitting smoking as you do.
  • Do not use Zyban® for the treatment of other diseases without the advice of a doctor.

Special instructions

Caution should be exercised when driving a car or performing any other work that requires a high speed of mental and physical reactions until you know what effect Ziban® has on you.

Like many other medicines, in some people Zyban® can cause:

  • dizziness
  • drowsiness
  • fatigue
  • change in concentration
  • Vision changes

Side effects

Contact your doctor or pharmacist as soon as possible if you do not feel well enough while taking Zyban®, even if you do not expect it to be related to taking the medicine or if you find any side effects not mentioned in these instructions.

All medicines may have side effects, including Zyban®. In most cases, the side effects of Zyban® are minor and transient. For a number of side effects, you may need emergency medical attention. Common side effects:

  • Headache
  • Sleep disturbance (see section "How to take Zyban®")
  • Dry mouth
  • Indigestion (e.g. nausea and constipation)

If you have any questions, contact your doctor or pharmacist for help. Tell your doctor or pharmacist immediately if you notice any of the following:

  • Fever
  • Fatigue
  • Flushing
  • Unsteadiness gait
  • Anorexia (loss of appetite)
  • Tinnitus
  • Visual impairment
  • Taste disorder
  • Loss of appetite
  • Affective Disorder (mood disorder)
  • Impaired concentration
  • Irritability
  • Hostility and Aggression
  • Feeling anxious
  • Hallucinations
  • Rave
  • Suicidal mood
  • Anxiety
  • Dizziness
  • Rapid heartbeat
  • Tingling or numbness of limbs
  • Memory impairment
  • Changes in blood sugar

In some cases, there was a sharp increase in blood pressure. In the event of an acute allergic reaction to the drug, Zyban should immediately inform your doctor or seek emergency medical attention.

Symptoms of an allergic reaction may include some or all of the following:

  • Dyspnea
  • Swelling of the eyelids, lips, larynx
  • Difficulty breathing
  • Hay fever (allergic rhinitis)
  • Hives
  • Loss of consciousness

There is a likelihood of an epileptic seizure occurring in about 1 out of 1,000 people taking bupropion hydrochloride (the active component of Zyban). The risk of an epileptic seizure increases if you:

  • Suffer or have ever suffered from any form of epilepsy  
  • Suffer or have suffered from an eating disorder (bulimia or anorexia)
  • Take more than the prescribed dose of Zyban®  
  • Take any other medicines that contain bupropion (such as antidepressants)
  • Suffered a head injury
  • Addicted to alcohol
  • Suffer from diabetes

The concomitant use of other drugs may lead to a risk of an epileptic seizure (see the section “Interaction with other drugs”). You must inform your doctor about all medications that you take or plan to take during the course of treatment. Strictly observe the dosage prescribed by the doctor and the frequency of use of Zyban tablets.

These instructions provide an incomplete list of possible side effects. Some people may have other side effects not listed above. Effect of quitting smoking initiates the development of symptoms of nicotine withdrawal syndrome. A similar condition was reported by patients taking the drug during the course of treatment for nicotine addiction. The following symptoms include:

  • Sleep disturbance, trembling, or excessive sweating
  • Feeling anxious or depressed (rarely suicidal thoughts)

If you feel any changes in mood, talk to your healthcare provider as soon as possible. Tell your doctor about all side (unusual) effects that you had while taking Ziban®, including those not listed on this list. Don't worry about this list of negative side effects. Most likely, none of them will manifest itself in you.

Storage conditions

The drug Ziban® should be stored in a dry, cool and out of reach of children at a temperature not exceeding 25 ° C.

The best place to store medicines is a wall-mounted locker, locked with a key, hanging at a height of at least 1.5 meters from the floor. Do not store in the bathroom or near the sink.

Do not leave Zyban tablets in a car or on a windowsill. Heat and moisture can ruin some medicines. Store the tablets in blister packs until the next dose. Do not remove the tablets from the blister pack, as their safety is lost.

Disposal of medicines If the doctor has stopped the treatment with Zyban® or the tablets have expired, ask your pharmacist what to do with the remaining medicines.

Dosage form

White film-coated tablets, round biconvex, engraved with "GX CH7" on one side. Zyban® tablets are available in foil blister packs. Packed in a blister pack of 10 pcs., Which is placed in a cardboard box.

Composition: active ingredient: bupropion hydrochloride 150 mg excipients:

  • microcrystalline cellulose (MCC),
  • hypromellose,
  • cysteine ​​hydrochloride monohydrate,
  • magnesium stearate,
  • macrogol 400,
  • titanium dioxide (E171),
  • carnauba wax,
  • black iron oxide pigment (E172).

Zyban tablets do not contain lactose (milk sugar). The tablets may have a characteristic odor, which is considered normal. Manufacturer name and address GlaxoSmithKline Pty Ltd (Australia) 1061 Mountain Highway Boronia VIC 3155, Australia.

Additional Information

Pharmaceutical companies are not able to diagnose or give medical advice to people. Only a qualified specialist can make the correct diagnosis and prescribe the appropriate treatment for the disease. You can also find general information about your disease and its treatment in books or on the Internet.

Do not discard this manual; you may need to read it again. This manual was prepared on April 30, 2008. The information provided in this manual is applicable only to Ziban®.